Is CdtB a Nuclease or a Phosphatase?

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Is CdtB a nuclease or a phosphatase?

Lara-Tejero and Galán (1) reported deoxyribonuclease (DNase) I–like activity of cytolethal distending toxin B (CdtB), which causes arrest in the G2/M transition phase of the cell cycle (2). Even though the authors noted that CdtB is a poor nuclease in vitro, they proposed that CdtB-inflicted DNA damage could trigger the checkpoint system that prevents cell entry into mitosis. A relationship bet...

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ژورنال

عنوان ژورنال: Science

سال: 2001

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.291.5504.547a