Irreducibility of integer-valued polynomials in several variables

Let $$\underline{S}$$ be an arbitrary subset of $$R^n$$ where R is a domain with the field fractions $$\mathbb {K}$$ . Denote ring polynomials in n variables over by {K}[\underline{x}] $$ The integer-valued , denoted Int $$(\underline{S},R)$$ defined as set which maps to R. In this article, we study irreducibility for first time case when Unique Factorization Domain. We also show that our results remain valid Dedekind or, sometimes, any domain.