منابع مشابه
Ironing out cancer.
New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have provided specificity and molecular definition to the role...
متن کاملIroning out Ferroportin.
Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through t...
متن کاملIroning out fatigue.
Women who are not anemic but who suffer from fatigue may benefit from iron supplementation. In this issue of Blood, Krayenbühl et al provide strong evidence that women complaining of fatigue who were not anemic but who had reduced or absent iron stores were symptomatically improved after receiving parenteral iron. Given the numbers of women who are iron deficient, the findings could find broad ...
متن کاملIroning out steatohepatitis.
The increasing prevalence of obesity and the metabolic syndrome worldwide is well recognized, the tight association of non-alcoholic fatty liver disease (NAFLD) with these conditions increasingly so. NAFLD can progress to the more severe form of the disorder non-alcoholic steatohepatitis (NASH), which is characterized by worsening liver pathology. The prevalence of iron disorders, in particular...
متن کاملIroning Out Cell Death Mechanisms
lamin gene (Lmna) develop an EDMD-like syndrome soon after birth and die within 6 weeks of cardiovascular disease. A recent publication by Chen et al. (2012) reports the remarkable finding that downregulation of Sun1 expression in Lmnadeficient mice significantly extended their life span along with amelioration of cardiac pathology. Thus, LINC complexes could represent viable therapeutic target...
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ژورنال
عنوان ژورنال: Science
سال: 2020
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.369.6499.46-f