منابع مشابه
CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.
The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.
متن کاملSynthesis and Evaluation of PARACEST MRI Contrast Agents Containing an Amino Acid Arginine
Introduction: Considering their excellent sensitivity to environmental conditions (e.g. temperature, pH), there is growing interest in the design and synthesis of paramagnetic chemical exchange saturation transfer (PARACEST) MRI contrast agents (CAs) (1). We have recently established a wide scope synthetic methodology for the preparation of mono-, diand tripeptide decorated cyclens and their la...
متن کاملPolymeric PARACEST MRI contrast agents as potential reporters for gene therapy.
Gene therapy is a potentially powerful treatment approach that targets molecular remedies for disease. Among other challenges it remains difficult to monitor gene delivery and its downstream metabolic consequences. Approaches to MRI gene reporters have been reported but few have the potential for translation beyond isolated cell systems. Herein, we report a polycationic polymer MRI contrast age...
متن کاملDevelopment of Spontaneously Disassembling Dendrimers as a Platform Technology for PARACEST MRI Contrast Agents
PARACEST MRI contrast agents have been incorporated into nanocarriers to improve PARACEST sensitivity. Spontaneously disassembling dendrimers are nanocarriers can carry high payloads of chemotherapies to pathological tissues, and then rapidly release the chemotherapies during enzyme-triggered spontaneous disassembly of the dendrimers. To investigate whether a spontaneously disassembling systems...
متن کاملTriethylenetetramine penta- and hexa-acetamide ligands and their ytterbium complexes as paraCEST contrast agents for MRI.
The ligand triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetamide (ttham) was synthesized with the aim of forming lanthanide complexes suitable as contrast agents for magnetic resonance imaging applications utilizing the chemical exchange-dependent saturation transfer (CEST) effect. It was designed to exclude water molecules from the first coordination sphere and provide a high number of CEST ...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2011
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja204297z