Iron Metabolism in Pregnancy

Hemodilution and iron metabolism in rats during pregnancy.

Studies were made on the cellular components of the blood, the serum iron concentration, and the circulating blood and plasma volumes of rats in pregnancy and on the iron transport from the maternal blood to the conception products (uterus and its contents) using radioactive iron. Anemia of pregnancy developed and was most pronounced during late pregnancy when the conception products developed ...

THE RELATIONSHIP BETWEEN ALUMINIUM TOXICITY AND IRON METABOLISM IN RATS

The relationship between aluminium toxicity and iron metabolism was studied. Male rats were exposed to aluminium by daily intraperitoneal injection of 40pmolelkg body weight. After 45 days, aluminium intoxified rats had a significant loweredserum ferritin (55%), iron (42%), TIBC (25%) and hemoglobin(31%). At thesame time the serum ceruloplasmin level was elevated by 60%. This result shows t...

Fetal iron status regulates maternal iron metabolism during pregnancy in the rat.

Iron metabolism during pregnancy is biased toward maintaining the fetal supply, even at the cost of anemia in the mother. The mechanisms regulating this are not well understood. Here, we examine iron deficiency and supplementation on the hierarchy of iron supply and the gene expression of proteins that regulate iron metabolism in the rat. Dams were fed iron-deficient diets for 4 wk, mated, and ...

Gambling et al FETAL IRON STATUS REGULATES MATERNAL IRON METABOLISM DURING PREGNANCY IN THE RAT

Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn Aberdeen AB21 9SB, UK Biomathematics and Statistics Scotland, Rowett Institute of Nutrition and Health, Greenburn Road, Aberdeen AB21 9SB, UK Dept of Biochemistry and Molecular Biology, Royal Free Hospital, Rowland Hill Road, London NW3 2QG, UK Department of Hygiene and Human Nutrition, Agricultural Univ...

Iron supplementation in pregnancy.