Iron Chelation Resulting in Renal Phosphate Wasting
نویسندگان
چکیده
منابع مشابه
Iron Chelation Resulting in Renal Phosphate Wasting
Lynda Cheddani, Thierry Leblanc, Caroline Silve, Nahid Tabibzadeh, Dominique Prié, Jean-Philippe Haymann, Marie-Noëlle Péraldi, Michel Daudon, Paul Meria and Emmanuel Letavernier Sorbonne Université UPMC Paris 06, UMR S 1155, Paris, France; INSERM, UMR S 1155, Paris, France; Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Paris, France; Service d’Hématologie, AP-HP, Hôpit...
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Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) enhance phosphate excretion by the proximal tubule of the kidney by retrieval of the sodium-dependent phosphate transporters (Npt2a and Npt2c) from the apical plasma membrane. PTH activates adenylyl cyclase (AC) through PTH 1 receptors and stimulates the cAMP/PKA signaling pathway. However, the precise role and isoform(s) of AC ...
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As a unique electron donor and acceptor, iron is an essential element in most biological systems. However, its chemical reactivity can result in iron potentially becoming a toxin when present in excessive quantities; accordingly, total body iron must be tightly regulated. As humans have no physiological mechanism for the elimination of excess iron, body iron is controlled mainly by the degree o...
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Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2018
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2017.07.011