IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes
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چکیده
منابع مشابه
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.
While the pro-differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here that interferon regulatory factor 6 (IRF6), an IRF family member with an essential role in epidermal development, is induced in differentiation through a Notch-dependent mechanism and is a primary Notch targe...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.325