منابع مشابه
Clinical trials make a move toward mice
Foretelling the future is often the stuff of science fiction but for a team of scientists at the Novartis Institutes for BioMedical Research (NIBR), it’s their end goal. Led by Juliet Williams, Director of Oncology Pharmacology, and Bill Sellers, Global Head of Oncology, the team has developed a unique system to help predict how cancer drugs might fare well before they enter clinical testing: A...
متن کاملHighlight: Nonmammalian Transcription Factors Make Mice Mothers Less Loving
For the first time, a complex behavior, mothers caring for their offspring, has been linked to a semimysterious repeating amino acid sequence common to mammals. These repeats, found more often in mammals than other vertebrates, have been seen in the past to affect protein–protein interactions, transcriptional regulation, and phenotypic variation. Japanese biologists Shintaroh Ueda, Den’etsu Sut...
متن کاملAutoimmune mice make anti-Fc gamma receptor antibodies
We demonstrate, using a recombinant truncated Fc gamma RII molecule as a probe, the presence of anti-Fc gamma R antibodies in several strains of autoimmune mice. Affinity chromatography on a truncated Fc gamma R column of pooled sera from aged NZB females resulted in isolation of 16 micrograms of IgM per ml of serum, approximately 2% of the total IgM; no anti-Fc gamma R IgM was found in sera fr...
متن کاملDoes loss of bile acid homeostasis make mice melancholy?
Bile is at the center of the traditional medicines of many cultures. For the ancient Greeks and Romans, each of the four macrocosmic elements that comprised the natural world, fire, earth, air, and water, had a specific microcosmic reflection in the four humors from which the body was constructed, yellow bile, black bile, blood, and phlegm. The view that imbalances in these components cause dis...
متن کاملC9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC
For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2009
ISSN: 1754-8705
DOI: 10.1038/stemcells.2009.106