Iohexol Versus Iothalamate for GFR Measurement

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Concordance Between Iothalamate and Iohexol Plasma Clearance.

To the Editor: Iohexol is regarded as an accurate filtration marker for measuring GFR. Recently, Soveri et al concluded that plasma clearance of iohexol could be considered a valid alternative to the gold standard, urinary clearance of inulin. Because inulin urinary clearance is cumbersome and costly, iohexol and iothalamate clearance have become popular in Europe and the United States, respect...

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Feasibility and impact of the measurement of extracellular fluid volume simultaneous with GFR by 125I-iothalamate.

The feasibility, validity, and possible applications of the assessment of extracellular fluid volume (ECFV) simultaneous with glomerular filtration rate (GFR) were assessed in a series of validation studies using the constant infusion method of (125)I-iothalamate (IOT). In 48 subjects with a broad range of GFR, distribution volume (V(d)) of IOT corresponded well with V(d) bromide (16.71 +/- 3.0...

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GFR measurement with iohexol and 51Cr-EDTA. A comparison of the two favoured GFR markers in Europe.

BACKGROUND The aim of the present study was to compare the most commonly used GFR markers for clearance measurements, 51Cr-EDTA and iohexol, using two different methods for iohexol analysis, HPLC and X-ray fluorescence, referring both to the multiple-sample and single-sample calculations, using 51Cr-EDTA as the reference method. METHODS Forty-nine patients with an estimated GFR >40 ml/min wer...

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GFR determined by nonradiolabeled iothalamate using capillary electrophoresis.

Traditional measurements of glomerular filtration rate (GFR) in clinical practice include the measurement of serum creatinine or creatinine clearance. Increasing evidence concerning the limitation of these measurements in clinical practice and clinical trials has resulted in efforts to develop technologies that improve measurement of GFR. Recent efforts in that regard have used radioisotopic la...

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Reproducibility of GFR measured by chromium-51-EDTA and iohexol.

We read with interest the article published by Bird et al about the reproducibility of measured GFR by iohexol and Cr-51-EDTA [ 1 ]. We would like to make one comment and to share our own results on this fundamental (although understudied) topic. As we already pointed out in a NDT editorial, we share the same reserves about the opportunity to index glomerular filtration rate (GFR) with body sur...

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ژورنال

عنوان ژورنال: American Journal of Kidney Diseases

سال: 2016

ISSN: 0272-6386

DOI: 10.1053/j.ajkd.2015.12.035