Iohexol plasma clearance simplified by dried blood spot testing
نویسندگان
چکیده
منابع مشابه
Swine by the Plasma Clearance of Iohexol
There is no simple method to measure glomerular filtration rate (GFR) in swine, an 15 established model to study renal disease. We developed a protocol to measure GFR in conscious 16 swine with the plasma clearance of iohexol. We used two groups: testing and validation, of 8 17 animals each. Ten milliliters of iohexol (6.47 g) were injected by the marginal auricular vein and 18 blood samples (3...
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To the Editor: Iohexol is regarded as an accurate filtration marker for measuring GFR. Recently, Soveri et al concluded that plasma clearance of iohexol could be considered a valid alternative to the gold standard, urinary clearance of inulin. Because inulin urinary clearance is cumbersome and costly, iohexol and iothalamate clearance have become popular in Europe and the United States, respect...
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INTRODUCTION Through the introduction of advanced analytical techniques and improved throughput, the scope of dried blood spot testing utilising mass spectrometric methods, has broadly expanded. Clinicians and researchers have become very enthusiastic about the potential applications of dried blood spot based mass spectrometric applications. Analysts on the other hand face challenges of sensiti...
متن کاملMeasurement of Creatinine from Dried Blood spot by Enzymatic Method
Background: DBS on filter paper has been shown as a feasible matrix for collection, transport and analysis of biochemical analytes. Creatinine, is used as a marker of renal function and staging chronic kidney disease (CKD), often requiring repeated testing for drug dosing in patients who undergo dialysis or those who have had arenal transplant. Blood collected and dried on filter paper would be...
متن کاملMeasurement and Comparison of Organic Compound Concentrations in Plasma, Whole Blood, and Dried Blood Spot Samples
The preferred sampling medium for measuring human exposures of persistent organic compounds (POPs) is blood, and relevant sample types include whole blood, plasma, and dried blood spots (DBS). Because information regarding the performance and comparability of measurements across these sample types is limited, it is difficult to compare across studies. This study evaluates the performance of POP...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfx323