Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain–Specific Interaction
نویسندگان
چکیده
منابع مشابه
Potassium ions as vasodilators: role of inward rectifier potassium channels.
External potassium ions have long been known as mediators of vasodilation of several vascular beds, including the coronary and cerebral circulations.1–6 Indeed, potassium ions have been viewed as communicators of the metabolic state of the cells that surround blood vessels. For example, release of potassium ions from neurons is communicated through glial cells to regulate cerebral artery diamet...
متن کاملInward rectifier potassium channels. Cloning, expression and structure-function studies.
A PCR-based cloning strategy was used to identify novel subunits of the two-transmembrane domain inward rectifier potassium channel family from rat brain, heart, and skeletal muscle. When expressed in Xenopus oocytes, two of these clones (Kir4.1 and Kir2.3) gave rise to inwardly rectifying potassium currents. Two-electrode voltage clamp commands to potentials negative to EK evoked inward potass...
متن کاملDescending vasa recta endothelia express inward rectifier potassium channels.
Descending vasa recta (DVR) are capillary-sized microvessels that supply blood flow to the renal medulla. They are composed of contractile pericytes and endothelial cells. In this study, we used the whole cell patch-clamp method to determine whether inward rectifier potassium channels (K(IR)) exist in the endothelia, affect membrane potential, and modulate intracellular Ca(2+) concentration ([C...
متن کاملInward rectifier potassium channels in the rat middle cerebral artery.
Inward rectifier K+ channels (Kirs) were studied in the isolated perfused rat middle cerebral artery (MCA). The addition of 15 mM K+ (KCl) to the extraluminal bath dilated the MCAs. These dilations were blocked by selective inhibitors for the Kirs (40 μM BaCl2 or 40 mM CsCl) but not selective inhibitors for other K+channels (glibenclamide, tetraethylammonium, or 4-aminopyridine). Neither remova...
متن کاملLong-pore Electrostatics in Inward-rectifier Potassium Channels
Inward-rectifier potassium (Kir) channels differ from the canonical K(+) channel structure in that they possess a long extended pore (approximately 85 A) for ion conduction that reaches deeply into the cytoplasm. This unique structural feature is presumably involved in regulating functional properties specific to Kir channels, such as conductance, rectification block, and ligand-dependent gatin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation: Arrhythmia and Electrophysiology
سال: 2018
ISSN: 1941-3149,1941-3084
DOI: 10.1161/circep.117.005800