Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG2) cells
نویسندگان
چکیده
منابع مشابه
Methyl Parathion and Parathion-induced Cyto-genotoxicity to Human Liver Carcinoma (hepg2) Cells via Oxidative Stress
Methyl parathion (C8H10NO5PS) and parathion (C10H14NO5PS) are both organophosphate insecticides (OPI) widely used for household and agricultural applications. They are known for their ability to irreversibly inhibit acetylcholinesterase which often leads to a profound effect on the nervous system of exposed organisms. Many recently published studies have indicated that human exposure to OPI may...
متن کاملPotassium Dichromate Induced Cytotoxicity, Genotoxicity and Oxidative Stress in Human Liver Carcinoma (HepG2) Cells
Chromium is a widespread industrial waste. The soluble hexavalent chromium Cr (VI) is an environmental contaminant widely recognized to act as a carcinogen, mutagen and teratogen towards humans and animals. The fate of chromium in the environment is dependent on its oxidation state. Hexavalent chromium primarily enters the cells and undergoes metabolic reduction to trivalent chromium, resulting...
متن کاملCytotoxicity, Oxidative Stress, and Genotoxicity in Human Liver Carcinoma (hepg2) Cells Exposed to Dinitrotoluenes
Dinitrotoluenes (DNTs) [CH3C6H3(NO2)2] are nitroaromatic compounds that are produced industrially and released into the environment as a result of human activities. DNTs appear as pale yellow crystalline solids and exist as a mixture of 2 to 6 isomers, among which 2,4-DNT and 2,6-DNT are the most significant The primary targets of DNTs toxicity are the hematopoietic system, cardiovascular syste...
متن کاملMolecular Basis of Arsenic-induced Cytotoxicity, Oxidative Stress, and Genotoxicity in Human Liver Carcinoma Cells
Arsenic is a ubiquitous trace element that has been shown to induce both systemic and carcinogenic effects. Epidemiological findings indicate that arsenic is a paradoxical human carcinogen that results in increased risk of skin, lung, bladder, liver and kidney cancers. Although the systemic and carcinogenic effects of arsenic have been widely studied in a variety of systems, the mechanisms of a...
متن کاملMethyl parathion comes inside.
Research Public health scientists are increasingly discovering that the recent emergence or re-emergence of infectious diseases has an origin in environmental change (McMichael and Martens 2002; Morse 1995; Patz et al. 2000). These environmental changes encompass social processes such as urbanization and creation of transportation infrastructure, as well as eco-logic processes such as land and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Toxicology
سال: 2011
ISSN: 1520-4081
DOI: 10.1002/tox.20725