Involvement of cell envelope in nisin resistance of Pectinatus frisingensis, a Gram-negative, strictly anaerobic beer-spoilage bacterium naturally sensitive to nisin

Nisin Resistance Protein NSR Proteolytic Degradation of Nisin by the Novel Mechanism for Nisin Resistance via

Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR.

Nisin is a 34-residue antibacterial peptide produced by Lactococcus lactis that is active against a wide range of gram-positive bacteria. In non-nisin-producing L. lactis, nisin resistance could be conferred by a specific nisin resistance gene (nsr), which encodes a 35-kDa nisin resistance protein (NSR). However, the mechanism underlying NSR-mediated nisin resistance is poorly understood. Here ...

Cell Envelope Structure and Functions in Gram-negative Bacteria

Effects of tylosin and nisin on canned food spoilage bacteria.

Many antibiotics have been screened for inhibition of sporeforming bacteria during the last 10 years in this laboratory. The effect of some of these antibiotics on canned food spoilage bacteria has previously been described (Denny and Bohrer, 1959). Recently, two antibiotics which eventually may be of use in food processing have been through a preliminary screening in this laboratory. These ant...

Nisin resistance of Streptococcus bovis.

The growth of Streptococcus bovis JB1 was initially inhibited by nisin (1 microM), and nisin caused a more than 3-log decrease in viability. However, some of the cells survived, and these nisin-resistant cells grew as rapidly as untreated ones. To see if the nisin resistance was merely a selection, nisin-sensitive cells were obtained from agar plates lacking nisin. Results indicated that virtua...