Invited Commentary: Testing for Hardy-Weinberg Disequilibrium Using a Genome Single-Nucleotide Polymorphism Scan Based on Cases Only
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Invited commentary: Testing for Hardy-Weinberg disequilibrium using a genome single-nucleotide polymorphism scan based on cases only.
Classical methods for localizing genes based on pedigrees and linkage have served well for genes that are “Mendelian,” that is, where genotype and phenotype are closely related. Geneticists now recognize that these methods do not work so well when applied to the more common, multifactorial diseases. Risch comments, “The gene mutations studied by Mendel, and those more recently discovered by pos...
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I appreciate Weinberg and Morris’ thoughtful commentary (1) on my paper (2). In their article, they put my work under the perspective of gene mapping in the postgenomic era. I share the same view with them that the method proposed in my paper amounts to a tree-shaking approach to harvesting the high-hanging fruit (a low-cost approach to generating hypotheses aimed at localizing diseasesusceptib...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2003
ISSN: 0002-9262
DOI: 10.1093/aje/kwg151