Investigation on Acute Phase Reactants and Oxidant - Antioxidant Parameters in Patients Diagnosed as Having Generalized Tonic Clonic Type Epilepsy on Antiepileptic Monotherapy and Polytherapy

Objective: This study aimed to investigate the relationship between acute-phase reactants and oxidative stress epilepsy. Methods: The patient group consisted of 67 patients who applied Pediatric Neurology outpatient clinic were diagnosed with generalized type epilepsy according ILAE classification, 33 receiving monotherapy 34 antiepileptic medication in form polytherapy. control included 30 healthy volunteer participants similar sociodemographic characteristics same age range, without or any known chronic disease. Total anti-Oxidant Status (TAS) total Oxidant (TOS) measured method developed by Erel, index (OSI) was calculated. Sensitive C-reactive protein (Hs-CRP) levels measured. Results: Both TOS OSI received polytherapy statistically significantly higher than (p = 0.004, 19.29 ± 1.27, 19.22 1.26, respectively, 14.49 1.75, 1.66 0.12, 1.72 0.11, 1.27 0.11), respectively. Hs-CRP level (0.59 0.06 mg / L, 1.09 respectively) significant compared (0.42 0.02 L) higher. Conclusion: In this study, findings suggest that epileptic seizures increase parameters antioxidant mechanisms are insufficient reduce damage. addition, considering high serum levels, it is extremely important develop treatment strategies can inflammatory process treating resistant