Investigation of the effectıveness of hyperthermic intraperitoneal chemotherapy in experimental colorectal peritoneal metastasis model

Abstract Objectives In our study, we aimed to (1) create a peritoneal metastasis (PM) model in nude mice, administer intraperitoneal chemotherapy using the infusion pump developed this model, and (2) compare efficacy of various drugs at different temperatures. Methods The was established mice CC531 colon carcinoma cell line. Models with were randomized into four groups seven animals each: Group 1, control group (n=7); 2, normothermic (NIPEC) mitomycin C(MMC) 3, hyperthermic (HIPEC) C (n=7), 4, NIPEC 5-fluorouracil (5-FU). Results Tumor development achieved all animals. While tumor burden decreased significantly treatment 3 (p=0.034), no significant difference found other groups. PM mouse administration MMC had highest tumoricidal effect. Conclusions Our provided good opportunity examine HIPEC (IPIP). future studies, plan evaluate efficacies models have created.