Investigation of the effects of St. John’s wort (Hypericum perforatum) oil on the methotrexate-induced gastrointestinal mucosa injury and hepatotoxicity in mice

St. John's wort oil is one of the herbal product which used for therapeutic purposes. To investigate effects Wort on irritated gastrointestinal mucosa and liver. The study based experimental animal trials. 21 healthy swiss albino mice were randomly divided into three groups: control group, group-2, group-3. methotrexate (20 mg/kg) was given intraperitoneally as a single dose 1st day to group-2 (4 ml/kg) administered by gavages stomach daily 7 days Following necropsy, samples liver tissue collected histopathological evaluation. No pathology found in group. group-3 examination gastric mucosa. Significant hyperplasia mononuclear cell infiltrations lamina propria observed group-2’s intestinal mice's similar group's In histopathology, locally degenerative changes periportal area, vascular congestion sinusoidal enlargement, thrombotic vessels, bile duct hyperplasia, megalocytosis hepatocytes some areas livers mice. Only mild enlargement noted group-3's According data we obtained our study, has protective restorative especially if it consciously.