Investigation of susceptible gas station workers to neurological disorders based on evidence of catechol -O- methyltransferase (COMT) gene expression alters
نویسندگان
چکیده
منابع مشابه
Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats.
Catechol-O-methyltransferase (COMT) activity depends on gender, age and physiological status suggesting that estrogen may regulate COMT activity. In fact, estrogens down-regulate the function of COMT promoters in cell cultures. On the other hand, COMT may play an important role in estrogen-induced cancers due to its ability to inactivate estrogen metabolites and thereby lowering the levels of t...
متن کاملGenetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms
People may experience an "aha" moment, when suddenly realizing a solution of a puzzling problem. This experience is called insight problem solving. Several findings suggest that catecholamine-related genes may contribute to insight problem solving, among which the catechol-O-methyltransferase (COMT) gene is the most promising candidate. The current study examined 753 healthy individuals to dete...
متن کاملImpact of catechol-O-methyltransferase (COMT) gene polymorphism on promoter methylation status in gastric mucosa.
UNLABELLED DNA methylation is one of the major events in the early process of gastric carcinogenesis and also occurs in non-neoplastic gastric mucosa. Catechol-O-methyltransferase (COMT) catalyzes the methylation of various endobiotic and xenobiotic substances, and protects DNA from oxidative damage. The association between a common functional polymorphism of COMT Val158Met and DNA methylation ...
متن کاملHypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians
Higher brain dopamine content depending on lower activity of Catechol-O-Methyltransferase (COMT) in subjects with high hypnotizability scores (highs) has been considered responsible for their attentional characteristics. However, the results of the previous genetic studies on association between hypnotizability and the COMT single nucleotide polymorphism (SNP) rs4680 (Val(158)Met) were inconsis...
متن کاملStudy of the catechol-o-methyltransferase (COMT) gene with high aggression in children.
The etiology of childhood-onset aggression (COA) is poorly understood, but early COA can be considered as a strong risk factor for adult delinquency and criminal behavior. Callous-unemotional (CU) traits have been proposed as a developmental model of antisocial behavior. Catechol O-methyltransferase (COMT) has been associated with aggression, attention deficit/hyperactivity disorder (ADHD), and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Biomedical Research
سال: 2019
ISSN: 2632-0509
DOI: 10.15761/jtbr.1000108