Investigation of IL-17A, IL-17F, IL-34 Levels of Patient with Multiple Sclerosis and Pseudotumor Cerebri

Objective: Multiple Sclerosis is an inflammatory demyelinating disease characterized by lymphocyte infiltration and demyelination of brain tissue central nervous system.
 Materials Methods: This study aimed to evaluate the interleukin (IL-17A, IL-17F, IL-34 cytokine) levels in cerebrospinal fluid Relapsing-Remitting (n=23), radiologically isolated syndrome (n=5) pseudotumor cerebri (n=15) cases. In this study, lumbar puncture obtained from patients who were diagnosed with aged between 21-55. The PTC group included 28-60 years. IL-17A, cytokines determined ELISA kit.
 Results: Among studied samples patients, median (min-max) values IL-17A for Demyelinated 50 (7-257) pg/ml 2 (1-6) respectively, a statistically significant difference (p<0.01) has been observed two groups. Median IL-17F 32 (6-891) (1-3) 16 (4-197) (1-11) groups (Lower limit cytokine have as IL-17A: 3,93 pg/ml, IL-17F: 2,23 IL-34: 3,12 pg/ml). IL-34, was found be high sclerosis patients. important cerebral endothelial reaction sclerosis.
 Conclusion: suggest that it may new treatment strategy adjunct diagnosis neuroinflammatory neurodegenerative diseases such multiple disease. More extensive studies are needed determine whether can marker return clinical MS.