Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives
نویسندگان
چکیده
منابع مشابه
Interaction of Metal Ions with 7-Deaza-8-aza- and 8-Aza-purines Preparation and X-Ray Structural Analysis of Copper(II) Complexes
Fachbereich Chemie der Universität Kaiserslautern, Erwin-Schrödinger-Straße, D-6750 Kaiserslautern Z. Naturforsch. 42b, 195-202 (1987); received August 18/October 17, 1986 8-Azapurines, Allopurinol, Copper(II) Complexes, X-Ray The reaction of 8-azaand 7-deaza-8-aza-purines with Cu : + cations in acid solution has been studied. At a pH value of 2, the 8-azaadenine complex [Cu(H20)4(AAdH)2](N03)2...
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Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is a trimeric enzyme that readily dissociates to the monomer. Dilution of enzyme from 20 to 0.02 pg of protein/ml is accompanied by a greater than 50-fold increase in the specific activity (utrimer = 0.23 nmol/min/pg; umonomer = 12.5 nmol/min/pg). Gel permeation chromatography in the presence of the substrate phosphate shows the en...
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Some novel as well as known derivatives of 8-sulfanyl-3,9dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg/kg via i.p. injection for 15 days. Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique. The assay results showed decrease in the hormonal concentratio...
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ducing carcinostasis, with tumor cells resistant to thio guanine, has been suggested (9). The aand @9-anomers of 2'-deoxythioguanosine (TGDR) have been shown to be active against ascites tumors having either of two types of resistance to thioguanine (10). The kinases necessary for conversion of these nucleosides to nucleotides were apparently present in the tumor cell lines examined. How ever, ...
متن کاملIncorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells
7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxodG) is a well-known marker of oxidative stress. We report a mechanistic analysis of several pathways by which 8-oxodG is converted to nucleotide triphosphates and incorporated into both DNA and RNA. Exposure of MCF-7 cells to [(14)C]8-oxodG combined with specific inhibitors of several nucleotide salvage enzymes followed with accelerator mass spectrometr...
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ژورنال
عنوان ژورنال: Molecules
سال: 2019
ISSN: 1420-3049
DOI: 10.3390/molecules24050983