Investigating the relation between chromosomal polymorphism and recurrent pregnancy loss: A cohort study
نویسندگان
چکیده
Chromosomal polymorphisms (CPM) are minor variation of karyotype, found in >1% the general population. Heterochromatin, inactive part chromosome, shows frequent polymorphism - increase/decrease length. Recently, studies show that heterochromatin is not inert, but contains genes essential for spindle attachment, chromosome movement, meiotic pairing, and sister chromatid cohesion. Balanced translocation parents, reciprocal robertsonian, can disrupt important genes, produce gametes with unbalanced gene dosage, causing spontaneous miscarriage. To correlate between chromosomal polymorphisms/ structural alterations first trimester Recurrent Pregnancy Loss (RPL) primary infertility. : 100 couples infertility or RPLs, were karyotyped by 72-h whole blood culture. Giemsa banding (GTG) was done all cases. 20 metaphases analysed according to ISCN criteria. The total no. RPLs noted each couple abnormal karyotype. Of 44 36 (82%) had polymorphism, 7 (16%) showed abnormality 1 (2%) numerical abnormality. Chromosome 9qh+ present majority (33.33%). Among D, G chromosomes, 15ps+/pstk+ 22.22% average RPL 2.15, whereas Chr.22ps+ (incidence 5.55%.) 3 (highest). male partners, Chr.Yqh+/Yqh- 12 (33.33%) couples. abnormalities (16%), balanced accounted 11.36%, maximum which Reciprocal translocations. frequency higher among infertility, compared Karyotyping gives genetic information, thus acting as a good diagnostic tool, helps plan ART perform prenatal testing.
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ژورنال
عنوان ژورنال: Indian Journal of Obstetrics and Gynecology Research
سال: 2022
ISSN: ['2394-2746', '2394-2754']
DOI: https://doi.org/10.18231/j.ijogr.2022.074