Investigating the effect of Satureja Khusestanica essential oil on chlorpyrifos-induced spleen toxicity in male Wistar rats

Background: Chlorpyrifos is a type of organophosphorus poison that, despite its widespread use, can lead to tissue damage, including spleen tissue. Khuzestani savory plant has antioxidant properties and effective in reducing damage caused by oxidative stress. The aim this study was investigate the effect essential oil on chlorpyrifos-induced toxicity male Wistar rats. Materials Methods: In experimental research, 28 adult rats weighing between 180-220 grams were selected divided into 4 groups 7. Were examined. Statistical comparison control group, 25 mg/kg, chlorpyrifos 0.01 mg/kg + using SPSS 22 software square test Chi performed with Monte Carlo simulation under significance level 0.05. Results: Chi-square showed that there statistically significant difference different terms distribution types (P=0.005); So, such as macrophage pigment accumulation white pulp analysis observed, while no observed other groups. Conclusion: Our Khuzestan preventing due compounds carvacrol. Also, considering negative effects doses recommended World Health Organization, further investigations are necessary.