Investigating a back door mechanism of actin phosphate release by steered molecular dynamics
نویسندگان
چکیده
منابع مشابه
Investigating a back door mechanism of actin phosphate release by steered molecular dynamics.
In actin-based cell motility, phosphate (Pi) release after ATP hydrolysis is an essential biochemical process, but the actual pathway of Pi separation from actin is not well understood. We report a series of molecular dynamics simulations that induce the dissociation of Pi from actin. After cleavage from ATP, the singly protonated phosphate (HPO4(2-)) rotates about the ADP-associated Ca2+ ion, ...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 1999
ISSN: 0887-3585,1097-0134
DOI: 10.1002/(sici)1097-0134(19990501)35:2<262::aid-prot11>3.3.co;2-e