Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement

Acute and sub-chronic toxicity studies of a standardized extract of Centella asiatica ECa 233

Acute toxicity study of Centella asiatica standardized extract ECa 233 was conducted by an oral administration of 10.0 g/kg extract into 10 male and 10 female mice. The extract at the given dose did not cause any toxic signs and death within the observation period of 14 days. Sub-chronic toxicity study of ECa 233 has been investigated in four groups of Wistar rats, each of 24 rats (12 of each s...

Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells

BACKGROUND In order to gain insight into neuroprotective effects of ECa 233, a standardized extract of Centella asiatica, previously demonstrated in animal models of memory impairment induced by transient global ischemia or intracerebroventricular injection of β-amyloid, the effect of ECa 233 on neurite outgrowth of human IMR-32 neuroblastoma cell line was investigated. METHODS Cells were see...

Profiling of Centella Asiatica (l.) Urban Extract

Centella Asiatica is one of those phytochemical that has been consume for hundreds years and it is claimed that the plant possess various healing effect and antioxidant properties. For many years, a lot of commercial and medicinal researches have been focusing their resources on this plant. Hence, the profiling of this plant is vital. This study was done to investigate the behaviour of active c...

Title: Neuritogenic Effect of Standardized Extract of Centella Asiatica Eca233 on Human Neuroblastoma Cells

Neurotrophic activity of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells

Inter-disciplinary Program in Physiology, Graduate School, Chulalongkorn University, Bangkok, Thailand. Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. Cell-based Drug and Health Product Development Research Unit., Chulalongkorn University, Bangkok, Thailand. Faculty of Dentistry, Mahidol University, Bangkok, Thailand D...