Invasive Meningococcal Disease and a Need to Understand Host Genetic Susceptibility

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis.

Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provid...

Need for Optimisation of Immunisation Strategies Targeting Invasive Meningococcal Disease in the Netherlands

Invasive meningococcal disease (IMD) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. In recent years, industrialised countries have implemented vaccines targeting IMD in their National Immunisation Programmes (NIPs). In 2002, the Netherlands successfully implemented a single dose of meningococcal serogroup C conjugate vaccine at the age of 14 months a...

need for optimisation of immunisation strategies targeting invasive meningococcal disease in the netherlands

invasive meningococcal disease (imd) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. in recent years, industrialised countries have implemented vaccines targeting imd in their national immunisation programmes (nips). in 2002, the netherlands successfully implemented a single dose of meningococcal serogroup c conjugate vaccine at the age of 14 months a...

Epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in Ontario, Canada, 2000 to 2006.

Neisseria meningitidis has been relatively slow to acquire resistance to penicillin. We previously reported an increase in the incidence of invasive meningococcal disease (IMD) strains with decreased susceptibility to penicillin (DSP) in Ontario. Our objectives were to evaluate trends in IMD with DSP, to identify case-level predictors of IMD with DSP, and to evaluate the relationship among DSP,...

Invasive meningococcal disease in childhood.