منابع مشابه
CCR Translations Trastuzumab : A Picky Partner ?
Preclinical and clinical models of HER2-positive breast cancer show that human epidermal growth factor receptor 2 (HER2)-targeted therapy with trastuzumab adds significant benefits and modest risks to conventional cytotoxic therapies. Building on this advance will likely depend on elucidation of relevant signaling pathways and mechanisms of action for effective HER2-targeted therapies. (Clin Ca...
متن کاملIntroducing CCR perspectives in drug approval.
In this issue of Clinical Cancer Research, we are pleased to introduce a new feature titled CCR Perspectives in Drug Approval. This feature will incorporate the popular Report from the FDA but will evolve to include perspectives from other regulatory groups addressing broad topics that affect the drug approval process, as well as discussions of how national regulatory bodies are approaching the...
متن کاملCCR Translations Trastuzumab : A Picky Partner ? □ □ Commentary on Francia
Preclinical and clinical models of HER2-positive breast cancer show that human epidermal growth factor receptor 2 (HER2)-targeted therapy with trastuzumab adds significant benefits and modest risks to conventional cytotoxic therapies. Building on this advance will likely depend on elucidation of relevant signaling pathways and mechanisms of action for effective HER2-targeted therapies. (Clin Ca...
متن کاملCCR Translations Bringing DNA Repair in Tumors into Focus
In this issue of Clinical Cancer Research, Bañuelos and colleagues assess H2AX phosphorylation as a predictive biomarker of response to DNA damaging agents that cause double strand breaks (DSBs) (ref. 1). DSBs, where breaks in both strands of DNA occur in close vicinity, are especially lethal to replicating cells. This sensitivity has long been exploited in cancer therapy; radiotherapy and a wi...
متن کاملCCR Translations Tumor Endothelial Cells Join the Resistance
In this issue of Clinical Cancer Research, Xiong and colleagues report that isolated tumor-specific endothelial cells (TECs) from human hepatocellular carcinoma (HCC) are less sensitive to cytotoxic and antiangiogenic drugs when compared to their normal counterparts in vitro (1). The results of this study are in good accord with the growing body of in vivo evidence and clinical data suggesting ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2008
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-14-15-ed