Introducing CCR Focus

Introducing CCR perspectives in drug approval.

In this issue of Clinical Cancer Research, we are pleased to introduce a new feature titled CCR Perspectives in Drug Approval. This feature will incorporate the popular Report from the FDA but will evolve to include perspectives from other regulatory groups addressing broad topics that affect the drug approval process, as well as discussions of how national regulatory bodies are approaching the...

IntroducInG the Focus Group MethodoloGy

CCR FOCUS Resistance to Trastuzumab in Breast Cancer

HER2 is a transmembrane oncoprotein encoded by the HER2/neu gene and is overex-

CCR Translations Bringing DNA Repair in Tumors into Focus

In this issue of Clinical Cancer Research, Bañuelos and colleagues assess H2AX phosphorylation as a predictive biomarker of response to DNA damaging agents that cause double strand breaks (DSBs) (ref. 1). DSBs, where breaks in both strands of DNA occur in close vicinity, are especially lethal to replicating cells. This sensitivity has long been exploited in cancer therapy; radiotherapy and a wi...

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Intercellular communication was long thought to be regulated exclusively through direct contact between cells or via release of soluble molecules that transmit the signal by binding to a suitable receptor on the target cell, and/or via uptake into that cell. With the discovery of small secreted vesicular structures that contain complex cargo, both in their lumen and the lipid membrane that surr...