Introducing Bacteria and Synthetic Biomolecules along Engineered DNA Fibers

نویسندگان

چکیده

Deoxyribonucleic acid (DNA) nanotechnology enables user-defined structures to be built with unrivalled control. The approach is currently restricted across the nanoscale, yet ability generate macroscopic DNA has enormous potential applications spanning material, physical, and biological science. To address this need, I employed developed a new macromolecular nanoarchitectonic assembly method produce fibers customizable properties. process involves coalescing nanotubes under high salt conditions yield filament superstructures. Using strategy, over 100 microns long, stiffnesses 10 times greater than cytoskeletal actin filaments can fabricated. framework functionalized advanced synthetic molecules, including, aptamers, origami, nanoparticles, vesicles. In addition, act as bacterial extracellular scaffolds adhere Escherichia coli cells in controllable fashion. These results showcase opportunities offered from scale. biophysical should find widespread use, generation of hybrid-fabric materials, smart analytical devices biomedicine, platforms study cell-cell interactions.

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ژورنال

عنوان ژورنال: Small

سال: 2021

ISSN: ['1613-6829', '1613-6810']

DOI: https://doi.org/10.1002/smll.202100136