Intrinsically disordered protein regions at membrane contact sites

Membrane contact sites (MCS) are regions of close apposition between membrane-bound organelles. Proteins that occupy MCS display various domain organisation. Among them, lipid transfer proteins (LTPs) frequently contain both structured domains as well intrinsic disorder. In this review, we discuss the roles intrinsically disordered protein (IDPRs) in LTPs other associated with organelle sites. We distinguish following functions: (i) to act flexible tethers two membranes; (ii) entropic barriers prevent crowding and regulate membrane tethering geometry; (iii) define action range catalytic domains. These functions added IDPRs environments, such mediating protein-protein protein-membrane interactions. suggest overall efficiency fidelity might require fine coordination all these IDPR activities.