Intrinsic Neuronal Excitability: A Role in Homeostasis and Disease
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چکیده
منابع مشابه
Intrinsic Neuronal Excitability: A Role in Homeostasis and Disease
The neuronal components of brain circuitry are generally considered “stable” throughout an animals’ life; with the exception of times of growth and degeneration that occur during development, aging, or pathology. To maintain this stability, neurons must achieve a balance between changing output to meet new requirements, and keeping output within a satisfactory operating range. This balancing ac...
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A goal of many laboratories that study aging is to find a key cellular change(s) that can be manipulated and restored to a young-like state, and thus, reverse the age-related cognitive deficits. We have chosen to focus our efforts on the alteration of intrinsic excitability (as reflected by the postburst afterhyperpolarization, AHP) during the learning process in hippocampal pyramidal neurons. ...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2012
ISSN: 1664-2295
DOI: 10.3389/fneur.2012.00050