Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma
نویسندگان
چکیده
منابع مشابه
Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma.
AIM To develop and assess a protocol for the treatment of intraocular lymphoma by intravitreal injection of methotrexate and thiotepa. METHODS A patient with intraocular non-Hodgkin's lymphoma which recurred after radiotherapy and repeated systemic chemotherapeutic regimens underwent repeated intravitreal injections of methotrexate and thiotepa. The patient was closely monitored by cytology, ...
متن کاملPharmacokinetics and toxicity of intravitreal chemotherapy for primary intraocular lymphoma.
OBJECTIVE To investigate the pharmacokinetics and toxicity of intravitreal chemotherapeutic agents in the rabbit eye for the potential treatment of primary intraocular lymphoma and other intraocular malignancies. METHODS The ocular pharmacokinetics of intravitreal methotrexate sodium (400 microg) was studied in 10 New Zealand white rabbits, and a single-compartment, first-order elimination mo...
متن کامل[Intravitreal rituximab for the treatment of intraocular relapse of non-Hodgkin's lymphoma].
CLINICAL CASE A 58-year-old woman with intraocular relapse of a diffuse large B cell lymphoma. Weekly intravitreal rituximab (1 mg/0.1 ml) for 4 weeks were administered. 12 months after the last intravitreal rituximab dose, signs and symptoms of lymphomas or adverse reactions associated with intravitreal Rituximab administration were not observed. DISCUSSION Intravitreal rituximab is an ef...
متن کاملIntravitreal rituximab for the treatment of a secondary intraocular relapse of a large B-cell lymphoma
Purpose To report a rare case of secondary intraocular lymphoma treated with intravitreal rituximab, following pars plana vitrectomy. Observations A 74-year-old female with history of parotid gland large B-cell lymphoma presented bilateral intraocular recurrence 10 years after the onset of the primary malignancy. Systemic work-up including PET/CT Scan, bone marrow biopsy, brain MRI and CSF an...
متن کاملManagement of non Hodgkin's intraocular lymphoma with intravitreal methotrexate.
Intraocular non Hodgkin's lymphoma has traditionally been treated with radiotherapy or systemic chemotherapeutic agents. Unfortunately, radiotherapy rarely leads to a long term remission, and can only be safely administered once. Systemic chemotherapy has limited intraocular penetration. Intravitreal administered methotrexate is highly effective at inducing remission and is well tolerated. A ca...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1999
ISSN: 0007-1161
DOI: 10.1136/bjo.83.4.448