Intravenous Phosphate Loading Increases Fibroblast Growth Factor 23 in Uremic Rats
نویسندگان
چکیده
منابع مشابه
Intravenous Phosphate Loading Increases Fibroblast Growth Factor 23 in Uremic Rats
Oral phosphate loading and calcitriol stimulate Fibroblast growth factor 23 (FGF23) secretion, but the mechanisms underlying the stimulation of FGF23 remain to be studied. We compared the effect of intravenous phosphate loading with that of oral loading on FGF23 levels in normal and 5/6 nephrectomized uremic rats. Uremic rats (Nx) and sham-operated rats were fed a normal phosphate diet for 2 we...
متن کاملFibroblast Growth Factor-23—A Potential Uremic Toxin
Fibroblast growth factor-23 (FGF23) is a circulating member of the FGF family produced mainly by the osteocytes and osteoblasts that can act as a hormone. The main action of FGF23 is to lower phosphatemia via the reduction of urinary phosphate reabsorption and the decrease of 1,25(OH)₂-D generation in the kidney. In the course of chronic kidney disease (CKD), plasma FGF23 concentration rises ea...
متن کاملFibroblast growth factor 23 and its role in phosphate homeostasis.
Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network ...
متن کاملFibroblast Growth Factor 23 (FGF23) and Disorders of Phosphate Metabolism
Derangements in serum phosphate level result in rickets/osteomalacia or ectopic calcification indicating that healthy people without these abnormalities maintain serum phosphate within certain ranges. These results indicate that there must be a regulatory mechanism of serum phosphate level. Fibroblast growth factor 23 (FGF23) was identified as the last member of FGF family. FGF23 is produced by...
متن کاملIncreased Urinary Phosphate Excretion Induced by Fibroblast Growth Factor 23 in Zinc-deficient Rats
Zinc (Zn) is an essential trace element that is an important nutrient cofactor of numerous enzymes, transcription factors, and an intracellular signaling mediator . Physiological Zn is a cofactor of more than 300 enzymes, and more than 2,000 Zn-dependent proteins involved in stabilizing protein structures. Zn deficiency leads to anorexia, loss of appetite, failure of smell and taste, human grow...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0091096