Intravenous Lacosamide in refractory nonconvulsive status epilepticus
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چکیده
منابع مشابه
Intravenous Lacosamide in refractory nonconvulsive status epilepticus
BACKGROUND Many patients present with refractory Status epilepticus (SE) despite multiple anti-epileptic drugs (AEDs). Lacosamide (LCM) was recently approved as an adjunct AED for partial-onset seizures. It has unique mechanism of modulating voltage-gated sodium channels by enhancing their slow inactivation. LCM has demonstrated efficacy in animal models of pharmacoresistant seizures. To date, ...
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Prolonged, refractory status epilepticus is a rare clinical syndrome that is associated with severe morbidity and mortality. Lacosamide is a newly approved medication for treatment of partial onset seizures in adults, which has a novel mechanism of action. Experimental data and recent reports suggest that lacosamide could be effective in status epilepticus. We report a child with prolonged, ref...
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ژورنال
عنوان ژورنال: Seizure
سال: 2012
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2011.12.008