Intravenous Immunoglobulins: In-Depth Review of Excipients and Acute Kidney Injury Risk
نویسندگان
چکیده
منابع مشابه
Intravenous immunoglobulins: in-depth review of excipients and acute kidney injury risk.
BACKGROUND Used in a variety of approved and off-label indications, there are several intravenous immunoglobulin (IVIG) preparations available which differ in the excipients (e.g. sucrose, glucose, maltose, D-sorbitol, glycine or L-proline) used to stabilize the protein in the solution. A very rare, but severe adverse drug reaction (ADR) reported with sucrose-stabilized IVIGs, acute renal failu...
متن کاملIntravenous Immunoglobulins: In-Depth Review of Excipients and Acute Kidney Injury Risk
Background: Used in a variety of approved and off-label indications, there are several intravenous immunoglobulin (IVIG) preparations available which differ in the excipients (e.g. sucrose, glucose, maltose, D -sorbitol, glycine or L -proline) used to stabilize the protein in the solution. A very rare, but severe adverse drug reaction (ADR) reported with sucrose-stabilized IVIGs, acute renal fa...
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Acute renal failure (ARF) occurs in up to 30% of patients who undergo cardiac surgery, with dialysis being required in approximately 1% of all patients. The development of ARF is associated with substantial morbidity and mortality independent of all other factors. The pathogenesis of ARF involves multiple pathways. Hemodynamic, inflammatory, and nephrotoxic factors are involved and overlap each...
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STUDY OBJECTIVE The study objective was to determine whether intravenous contrast administration for computed tomography (CT) is independently associated with increased risk for acute kidney injury and adverse clinical outcomes. METHODS This single-center retrospective cohort analysis was performed in a large, urban, academic emergency department with an average census of 62,179 visits per ye...
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Background: Patients who undergo major orthopedic surgery are at risk of acute kidney injury (AKI) due to blood loss, electrolyte disorders, infection, and the presence of other co-morbidities. In this study, the frequency and risk factors of AKI were investigated. Objective & Methods: This study is a cross-sectional-analytical study with a sample size of 180 people. The studied population wer...
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ژورنال
عنوان ژورنال: American Journal of Nephrology
سال: 2013
ISSN: 1421-9670,0250-8095
DOI: 10.1159/000354893