Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep
نویسندگان
چکیده
منابع مشابه
Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep.
Central actions of angiotensin play an important role in cardiovascular control and have been implicated in the pathogenesis of hypertension and heart failure. One feature of centrally or peripherally administered angiotensin is that the bradycardia in response to an acute pressor effect is blunted. It is unknown whether after central angiotensin this is due partly to increased cardiac sympathe...
متن کاملCentral losartan blocks natriuretic, vasopressin, and pressor responses to central hypertonic NaCl in sheep.
This study investigated the effect of intracerebroventricular administration of the angiotensin AT1 receptor antagonist losartan on the natriuresis, pressor effect, and arginine vasopressin (AVP) secretion caused by intracerebroventricular infusion of either ANG II, hypertonic saline, or carbachol. Losartan (1 mg/h) or artificial cerebrospinal fluid (CSF) was infused into the lateral ventricle ...
متن کاملCerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions.
BACKGROUND The analgesic effects of morphine are delayed relative to its concentration in blood. The rate of equilibration of morphine between blood and brain may contribute to this delay, but the kinetics of this process have not been modelled. This was determined in conscious instrumented sheep. The lung kinetics of morphine were also determined given their importance in defining systemic kin...
متن کاملIntracarotid hypertonic sodium chloride differentially modulates sympathetic nerve activity to the heart and kidney.
Hypertonic NaCl infused into the carotid arteries increases mean arterial pressure (MAP) and changes sympathetic nerve activity (SNA) via cerebral mechanisms. We hypothesized that elevated sodium levels in the blood supply to the brain would induce differential responses in renal and cardiac SNA via sensors located outside the blood-brain barrier. To investigate this hypothesis, we measured ren...
متن کاملHypothalamic paraventricular nucleus mediates sodium-induced changes in cardiovascular and renal function in conscious sheep.
The contribution of the paraventricular nucleus of the hypothalamus (PVN) in mediating cardiovascular, renal, hormonal, and sympathetic nerve responses to increased cerebrospinal fluid (CSF) [Na(+)] was investigated in conscious sheep. Intracerebroventricular hypertonic NaCl (0.5 mol/l, 20 microl/min for 60 min) increased arterial blood pressure [AP; +13.4 (sd 2.0) mmHg, P < 0.001] and central ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2007
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2007.139592