Intravenous Formulation of N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for Inhibition of Rat Brain 20-Hydroxyeicosatetraenoic Acid Formation
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چکیده
منابع مشابه
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A.
We have previously reported that HET0016 [N-hydroxy-N'-(4-butyl-2 methylphenyl)formamidine], a selective inhibitor of CYP4A and thus 20-HETE (20-hydroxyeicosatetraenoic acid) synthesis, inhibits endothelial cell proliferation and decreases angiogenesis induced by human glioma cell U251. A stable 20-HETE agonist, WIT003 [20-hydroxyeicosa-5(Z),14(Z)-dienoic acid (1 microM)], increased U251 cell p...
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In the title benzamide derivative, C(11)H(14)ClNO, the chloro-benzene and butyl-amine groups are each planar, with mean deviations from the planes of 0.013 and 0.030 Å, respectively, and a dihedral angle of 2.54 (9)° between the two planes. In the crystal structure, N-H⋯O hydrogen bonds link mol-ecules in rows along a. Short inter-molecular Cl⋯Cl inter-actions [3.4225 (5) Å] link these rows int...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2008
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.108.023150