Intratumoral immunotherapy: using the tumour against itself
نویسندگان
چکیده
منابع مشابه
Intratumoral TNFα improves immunotherapy
Solid tumors are frequently resistant to immunotherapy. We demonstrated that low-dose tumor necrosis factorα (TNFα), when directly targeted to the tumor environment, exerts dual effects by improving vessel functionality and activating immune cells. This vascular remodeling in an inflammatory context enhances active immunotherapy and promotes tumor regression.
متن کاملIntratumoral immunotherapy with the TLR7/8 agonist 3M-052
TLR agonists have demonstrated anti-tumor activity in both animals and humans. Clinically, successful antitumor activity with TLR agonists was most often observed when the molecules were applied locally to dermatological cancers. This mode of administration was also associated with fewer and less severe adverse events (AEs) when compared to systemic administration. The efficacy of TLR agonists ...
متن کاملA house divided against itself cannot stand.
W siedzibie Rektoratu UTP odbył się konkurs krasmówczy dla uczniów z naszego regionu organizowany przez bydgoski oddział English Speaking Union oraz Koło Naukowo-Dyskusyjne Wspólny Język. Do ogólnopolskiego finału zakwalifikowali się Agnieszka Śledzik (I LO Nakło), Jakub Piekut (VII LO Bydgoszcz) (na zdjęciach) oraz Andrzej Chrostowski (VII LO Bydgoszcz), Monika Muszyńska (IX LO Bydgoszcz), Mic...
متن کاملIntratumoral immunotherapy of established solid tumors with chitosan/IL-12.
IL-12 is a potent antitumor cytokine that exhibits significant clinical toxicities after systemic administration. We hypothesized that intratumoral (i.t.) administration of IL-12 coformulated with the biodegradable polysaccharide chitosan could enhance the antitumor activity of IL-12 while limiting its systemic toxicity. Noninvasive imaging studies monitored local retention of IL-12, with and w...
متن کاملCancer immunotherapy by intratumoral injection of α-gal glycolipids.
UNLABELLED AIM/ BACKGROUND: To determine the feasibility and safety of intratumoral α-gal glycolipids injection for conversion of human tumors into autologous Tumor Associated Antigens (TAA) vaccine. α-Gal glycolipids bind anti-Gal--the most abundant antibody in humans. Pre-clinical studies indicated that injected α-gal glycolipids insert into tumor cell membranes, bind anti-Gal and target tumo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunology
سال: 2005
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2004.02001.x