Intratumoral concentration of estrogens and clinicopathological changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment
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چکیده
منابع مشابه
Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment.
Sex steroids play important roles in the development of many human breast carcinomas, and aromatase inhibitors are used for the anti-estrogen therapy. Recent studies have demonstrated that aromatase suppressed 5alpha-dihydrotestosterone (DHT) synthesis in breast carcinoma cells, but intratumoral concentration of androgens and its significance have not been reported in the breast carcinoma patie...
متن کاملIntratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast.
It is well known that sex steroids play important roles in the development of invasive ductal carcinoma (IDC) of the human breast. However, biological significance of sex steroids remains largely unclear in ductal carcinoma in situ (DCIS), regarded as a precursor lesion of IDC, which is partly due to the fact that the intratumoral concentration of sex steroids has not been examined in DCIS. The...
متن کاملDuctal carcinoma in situ.
Management of ductal carcinoma in situ (DCIS) has evolved from radical surgery to the option of a more minimally invasive approach. Data show that breast conservation surgery performed with administration of radiotherapy, like mastectomy, is feasible and safe. Because efforts to find a safe group for elimination of radiotherapy have resulted in data that conflict, radiotherapy still remains sta...
متن کاملبررسی میزان بیان آنزیم دایسر در نواحی in situ carcinoma در مقایسه با مناطق in vasive carcinoma در سرطان پستان
خلاصه : کارسینوم تهاجمی سینه پستان علت مرگ و میر حاصل از سرطان خانم ها در بسیاری از کشورها می باشد. این کارسینوم بدنبال کارسینوم در محل ایجاد می شود. در کارسینوم در محل سلول های توموری هنوز نتوانسته اند که از غشاء پایه عبور کنند. در عبور از مرحله کارسینوم در محل به مرحله تهاجمی، سلولهای سرطانی تغییرات مولکولی بسیاری پیدا میکنند که هنوز علت عده ای از آنها مشخص نشده است. در این مطالعه ما بررسی کر...
15 صفحه اولRecurrence following treatment of ductal carcinoma in situ with skin-sparing mastectomy and immediate breast reconstruction.
Skin-sparing mastectomy with immediate breast reconstruction can provide an excellent cosmetic result. Despite its increasing popularity, few studies have assessed the risk of recurrence when the procedure is used for the treatment of ductal carcinoma in situ. To evaluate the oncologic safety of skin-sparing mastectomy used for the treatment of ductal carcinoma in situ, the recurrence rate was ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2013
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2013.284