Intratracheal Administration of Endotoxin and Cytokines
نویسندگان
چکیده
منابع مشابه
Intratracheal Administration of Endotoxin Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats
PURPOSE This study was undertaken to determine the effects of intratracheal administration of endotoxin on hyperoxia-induced lung injury in neonatal rats. MATERIALS AND METHODS Newborn Sprague Dawley rat pups were divided into four experimental groups: normoxia control (NC), normoxia with endotoxin treatment (NE), hyperoxia control (HC), and hyperoxia with endotoxin treatment (HE) groups. In ...
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Our laboratory has developed a method of particle exposure whereby anesthetized rats intratracheally inhale, at a regulated breathing rate and pressure, an aerosolized test material. This method is capable of delivering considerable doses in a short time period and, unlike the commonly used method of intratracheal instillation, does so with an even particle distribution throughout the lung. Ear...
متن کاملRepeated intratracheal challenge with particulate antigen modulates murine lung cytokines.
When lungs of experimental animals are repeatedly challenged with Ag, pulmonary inflammation wanes via unknown mechanisms. We hypothesized that changes in the balance of lung cytokines are responsible for immune down-regulation to repeated Ag challenge. We used intratracheal (IT) challenge of primed C57BL/6 mice with SRBC and on various days after single (1IT) or triple (3IT) challenge counted ...
متن کاملThe Effects of the Intratracheal Administration of Foreign Serum
It has been possible to sensitize guinea pigs by the intratracheal administration of small amounts of horse or cow serum. The degree of sensitiveness is comparable to that obtained when the same doses of serum are injected into the peritoneal cavity. Nevertheless, relatively small amounts of foreign protein are slowly absorbed through the lining membranes of the lower respiratory tract. In sens...
متن کاملIntracellular uptake of recombinant superoxide dismutase after intratracheal administration.
We have previously demonstrated that recombinant human copper-zinc superoxide dismutase (rhCu,ZnSOD) is rapidly incorporated into cells of airways, respiratory bronchioles, and alveoli after intratracheal administration. The present study examines whether this cellular uptake is specific for rhCu,ZnSOD or whether other proteins are similarly incorporated into lung cells. Twenty-two newborn pigl...
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ژورنال
عنوان ژورنال: Clinical Immunology and Immunopathology
سال: 1994
ISSN: 0090-1229
DOI: 10.1006/clin.1994.1117