منابع مشابه
Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration.
Exendin, a member of the glucagon-like peptide-1 family, and its antagonist exendin(9-39) affect cognition and neuronal survival after their intranasal delivery. Here, we examined the uptake of radioactively labeled exendin(9-39) (I-Ex) by the olfactory bulbs, brain (minus pineal, pituitary, and olfactory bulb), cerebrospinal fluid, and cervical lymph nodes (C-node) as well as levels in serum a...
متن کاملIntranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study
OBJECTIVE Treatment of severe hypoglycemia with loss of consciousness or seizure outside of the hospital setting is presently limited to intramuscular glucagon requiring reconstitution immediately prior to injection, a process prone to error or omission. A needle-free intranasal glucagon preparation was compared with intramuscular glucagon for treatment of insulin-induced hypoglycemia. RESEAR...
متن کاملExploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes.
OBJECTIVE This study aimed to assess the efficacy and safety of our newly developed nasal glucagon-like peptide-1 (GLP-1) compound and injector. RESEARCH DESIGN AND METHODS Twenty-six patients with type 2 diabetes were enrolled in this double-blind placebo-controlled study. The nasal compound containing 1.2 mg of human GLP-1 (7-36) amide or placebo was administered immediately before every me...
متن کاملGlucagon antibodies and an immunoassay for glucagon.
Despite extensive knowledge of the amino acid composition of beef-pork glucagon, and of the physiologic changes induced by its administration to animals and man, the role of glucagon in the homeostatic regulation of blood glucose level in normal and abnormal states remains to be defined. This fundamental gap in knowledge is the result of the lack of a method sufficiently specific and sensitive ...
متن کاملIntranasal Corticosteroid Safety
The safety and effi cacy of intranasal corticosteroids (INCs) are well established for the management of allergic rhinitis, rhinosinusitis, and nasal polyps. As seen in numerous studies, INCs demonstrate markedly reduced systemic bioavailability compared with oral and even inhaled corticosteroids and have shown an excellent safety profi le over 3 decades of use. Nonetheless, concerns remain amo...
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ژورنال
عنوان ژورنال: Journal of Diabetes Science and Technology
سال: 2014
ISSN: 1932-2968,1932-2968
DOI: 10.1177/1932296814557518