Intramolecular interactions mediate pH regulation of connexin43 channels

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Structural bases for the chemical regulation of Connexin43 channels.

Connexins proteins associate with a variety of catalytic and non-catalytic molecules. Also, different domains of connexin can bind to each other, providing a mechanism for channel regulation. Here, we review some of these associations, placing particular emphasis on the intramolecular interactions that regulate Connexin43 (Cx43). We also describe some novel methods that allow for the characteri...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 1996

ISSN: 0006-3495

DOI: 10.1016/s0006-3495(96)79686-8