Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment.
نویسندگان
چکیده
منابع مشابه
Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment.
A six week course of cimetidine (1 g/day) healed peptic ulcers in 20 of 23 patients (14 with duodenal ulcer, nine with gastric ulcer). Reduction of basal acid output by 73% and peak acid output by 36% led to a rise in concentrations of intragastric aerobic bacteria and nitrate-reducing bacteria. While the mean intragastric concentration of nitrate was unchanged by treatment, there were statisti...
متن کاملBacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study.
BACKGROUND Gastric and duodenal bacterial overgrowth frequently occurs in conditions where diminished acid secretion is present. Omeprazole inhibits acid secretion more effectively than cimetidine and might therefore more frequently cause bacterial overgrowth. AIM This controlled prospective study compared the incidence of gastric and duodenal bacterial overgrowth in patients treated with ome...
متن کاملEffect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds.
Previous studies have suggested that profound inhibition of gastric acid secretion may increase exposure to potentially carcinogenic N-nitroso compounds. The aim of this study was to find out if the proton pump inhibitor omeprazole (20 mg daily) is associated with increased concentrations of potentially carcinogenic N-nitroso compounds in gastric juice. The volume of gastric contents, number of...
متن کاملDuodenal bacterial overgrowth during treatment in outpatients with omeprazole.
The extent of duodenal bacterial overgrowth during the pronounced inhibition of acid secretion that occurs with omeprazole treatment is unknown. The bacterial content of duodenal juice of patients treated with omeprazole was therefore examined in a controlled prospective study. Duodenal juice was obtained under sterile conditions during diagnostic upper endoscopy. Aspirates were plated quantita...
متن کاملSmall intestinal bacterial overgrowth: diagnosis and treatment.
Small intestinal bacterial overgrowth (SIBO) is a clinical condition characterized by a malabsorption syndrome due to an increase in microorganisms within the small intestine. The main mechanisms restricting bacterial colonization in the upper gut are the gastric acid barrier, mucosal and systemic immunity and intestinal clearance. When these mechanisms fail, bacterial overgrowth develops. Diar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 1982
ISSN: 0017-5749
DOI: 10.1136/gut.23.12.1048