INTRAEPITHELIAL LYMPHOCYTES SUBSETS IN CROHN’S DISEASE PATIENTS

Crohn’s disease is an autoimmune inflammatory bowel characterized with the chronic relapsing-remitting inflammation, mainly in terminal parts of small intestine and colon, as a result genetic predisposition or environmental factors influence. It associated impaired bacterial clearance changes immunological parameters what resulted disruption gastrointestinal tract ecosystem, formed by microbiome non-living components such mucus, food metabolites additives. Intraepithelial lymphocytes play important role mucosal immunity their phenotype functional profile largely determined composition affecting it (diet, smoking, seasonal changes, air pollution, hygiene, etc.). In this investigation intraepithelial large were shown patient well correlation clinical data was established. Obtained may be used hallmark immune inflammation gut make ideal candidate for targeting further immunoregulation adaptive response against autoantigens.