Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.
BACKGROUND Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. METHODS In a multicenter trial, we randomly assigned 204 patients with acute myocardial infarction to receive an intracoronary infusion of progenitor cells derived from bone marrow (BMC) or placebo medium into the infarct...
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Six of 101 patients with acute myocardial infarction whose coronary arteries were successfully recanalised died in cardiogenic shock one to 18 days after intracoronary thrombolysis. In one patient, cardiogenic shock was preceded by coronary artery reocclusion. On admission, serum creatine kinase was still normal in all six patients and there was significant ST elevation but no changes in the QR...
متن کاملMagnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction.
RATIONALE The success of cardiac stem cell therapies is limited by low cell retention, due at least in part to washout via coronary veins. OBJECTIVE We sought to counter the efflux of transplanted cells by rendering them magnetically responsive and imposing an external magnetic field on the heart during and immediately after injection. METHODS AND RESULTS Cardiosphere-derived cells (CDCs) w...
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Cardiosphere-derived cells (CDCs) are under clinical development and are currently being tested in a clinical trial enrolling patients who have undergone a myocardial infarction. CDCs are presently administered via infusion into the infarct-related artery and have been shown in early clinical trials to be effective agents of myocardial regeneration. This review describes the administration of C...
متن کاملResults of intracoronary stem cell therapy after acute myocardial infarction.
To assess the effect of autologous bone-marrow cell (BMC) therapy in patients with acute myocardial infarction in a rigorous double-blind, randomized, placebo-controlled trial. Patients with reperfusion >6 hours after symptom onset were randomly assigned in a 2:1 ratio to receive intracoronary BMC or placebo therapy 5 to 7 days after symptom onset. The patients were stratified according to age,...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2013.08.724