Intracerebroventricular drug administration
نویسندگان
چکیده
منابع مشابه
Intracerebroventricular drug administration in pigeons.
For many procedures used in behavioral pharmacology, the intracerebroventricular (ICV) route of drug administration is infrequently used due, in part, to the lack of a reliable technique for determining cannula patency in vivo. This study describes an in vivo technique for assessing ICV cannula patency in pigeons. The technique was applied in an experiment designed to evaluate several drugs, wh...
متن کاملIntracerebroventricular met-enkephalin administration modulates adjuvant arthritis.
The purpose of this study was to investigate the anti-inflammatory properties of intracerebroventricular met-enkephalin (met-enk) administration in an animal model of arthritis. Adjuvant arthritis was induced in rats by intradermal inoculation of mycobacterium butyricum and the effects of intraventricular met-enk+thiorphan (enkephalinase inhibitor) were studied. Treatment was initiated either s...
متن کاملTheoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review.
Clinically, central nervous system (CNS) disorders account for more hospitalisations and prolonged care than almost all other diseases combined. In the preclinical setting, the intracerebroventricular (ICV) route for cerebrospinal fluid (CSF) sampling or dose administration in rodent models of human CNS disorders has potential to provide key insight on the pathobiology of these conditions. Low ...
متن کاملThe effect of intracerebroventricular administration of CCK receptor agonist and antagonist in nerve-Iigated mice
In the present study the effect of intracerebroventricular (ICV) injection of cerulein, an agonist of CCK receptor and proglumide, a receptor antagonist for hyperalgesia induced by sciatic nerve ligation were investigated in mice. Subcutaneous administration of morphine caused anti-nociception in both intact and nerve-ligated mice. However, the response to opioids was lower in ligated mice as c...
متن کاملChronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats
Background: The memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (STZ) in rats through activation of oxidative stress, is accepted as sporadic Alzheimer’s disease (AD) model in most experimental studies. Dimethyl sulfoxide (DMSO) as a solvent is widely used in animal studies to have antioxidant effects as well. However, no report is available ab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational and Clinical Pharmacology
سال: 2017
ISSN: 2289-0882,2383-5427
DOI: 10.12793/tcp.2017.25.3.117