Intracellular angiotensin II activates rat myometrium
نویسندگان
چکیده
منابع مشابه
Lysosomal action of intracrine angiotensin II. Focus on "Intracellular angiotensin II activates rat myometrium".
FORTY YEARS AGO, Robertson and Khairallah (20) demonstrated that tritiated angiotensin II (ANG II) rapidly localized in myocyte nuclei and mitochondria after intracardiac injection. This finding was confirmed and expanded upon over the subsequent decades with the result that the notion of intracrine ANG II action is now widely accepted. Indeed, there is robust evidence that a variety of hormone...
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Angiotensin II (A II) produces a contraction of visceral and vascular smooth muscles of different species. The accompanying electrophysiological changes were measured on strips of rat myometrium at 35 degrees C using the double sucrose-gap technique. A II at concentrations from 5 x 10(-10) to 10(-6)M produces a depolarization and an increase in membrane conductance. This increase in membrane co...
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Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium. Ca2+ uptake by these fractions was studied in order to estimate the relative potential of the corresponding organelles for controlling intracellular Ca2+ activity. Ca2+ uptake properties of t...
متن کاملIntracellular angiotensin II: from myth to reality?
Introduction The importance of the renin-angiotensin system (RAS) was first recognised in 1934. 1 Extensive research started in the mid-1950s by Skeggs and co-workers, who identified the transformation of a decapeptide into an octapeptide by a factor from horse blood plasma. 2,3 At that time, the two pep-tides were called hypertensin I and hypertensin II. In the same year, the laboratory synthe...
متن کاملAngiotensin II activates a nitric-oxide-driven inhibitory feedback in the rat paraventricular nucleus.
The hypothalamic paraventricular nucleus (PVN) has been shown to play major obligatory roles in autonomic and neuroendocrine regulation. Angiotensin II (ANG) acts as a neurotransmitter regulating the excitability of magnocellular neurons in this nucleus. We report here that ANG also activates a nitric-oxide-mediated negative feedback loop in the PVN that acts to regulate the functional output o...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2011
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00123.2011