Intra-articular therapy with infliximab in psoriatic arthritis: efficacy and safety in refractory monoarthritis

[Intra-articular therapy with infliximab in psoriatic arthritis: efficacy and safety in refractory monoarthritis].

OBJECTIVE To evaluate efficacy and safety of intra-articular therapy (IA) with infliximab (IFX), in patients with psoriatic arthritis (PsA) and refractory monoarthritis. METHODS Four male and 1 female aged from 25 to 71 years and disease duration from 1 to 25 years, affected by PsA (CASPAR criteria) were observed . All patients were treated with immunomodulators (methotrexate, leflunomide, cy...

Infliximab in psoriatic arthritis

Combination therapy of infliximab and granulocyte/monocyte adsorption apheresis for refractory pustular psoriasis with psoriatic arthritis.

© 2013 The Authors. doi: 10.2340/00015555-1463 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Infliximab, a chimeric monoclonal immunoglobulin G (IgG) antibody against tumour necrosis factor alpha (TNF-α), is effective in patients with psoriasis, including pustular psoriasis and psoriatic arthritis (1). Infliximab results in a Psoriasis Area Sensitivity Index (PASI) 75 re...

Safety and efficacy of leflunomide and infliximab versus methotrexate and infliximab combination therapy in rheumatoid arthritis.

1. Bodolay E, Szekanecz Z, Dévényi K et al. Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD). Rheumatology 2005;44:655–61. 2. Sharp GC, Irvin WS, Tan EM et al. Mixed connective tissue disease – an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972;52:148–59. 3. Winn DM, Wolfe ...

Intra-articular steroid therapy in rheumatoid arthritis.

The introduction of steroid preparations into joint cavities has become a routine method of treating some cases of rheumatoid arthritis. Murdoch and Will (1959a, b) have drawn attention to the persistence of prednisolone trimethyl acetate (P.T.M.A.) in the joint cavity and to its, apparently, purely local effect when administered in this way. Since then, Triamcinolone (T.C.A.), Dexamethasone (D...