Into Thin Air and Back: Deer Mouse Study Examines High-Altitude Adaptation

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Into Thin Air and Back: Deer Mouse Study Examines High-Altitude Adaptation.

Life has adapted to all sorts of extreme environments on Earth, among them, animals such as the deer mouse, shimmying and shivering about, and having to squeeze enough energy from the cold, thin air to fuel their bodies and survive. Now, Scott et al. (2015) have examined the underlying muscle physiology from a group of highland and lowland deer mice. Deer mice were chosen because they exhibit t...

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NEWS Into Thin Air and Back: Deer Mouse Study Examines High-Altitude Adaptation

Life has adapted to all sorts of extreme environments on Earth, among them, animals such as the deer mouse, shimmying and shivering about, and having to squeeze enough energy from the cold, thin air to fuel their bodies and survive. Now, Scott et al. (2015) have examined the underlying muscle physiology from a group of highland and lowland deer mice. Deer mice were chosen because they exhibit t...

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Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin.

Adaptive modifications of heteromeric proteins may involve genetically based changes in single subunit polypeptides or parallel changes in multiple genes that encode distinct, interacting subunits. Here we investigate these possibilities by conducting a combined evolutionary and functional analysis of duplicated globin genes in natural populations of deer mice (Peromyscus maniculatus) that are ...

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The Molecular Basis of High-Altitude Adaptation in Deer Mice

Elucidating genetic mechanisms of adaptation is a goal of central importance in evolutionary biology, yet few empirical studies have succeeded in documenting causal links between molecular variation and organismal fitness in natural populations. Here we report a population genetic analysis of a two-locus alpha-globin polymorphism that underlies physiological adaptation to high-altitude hypoxia ...

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' Adaptation to High Altitude

Hypoxia is inconsequential for physiologically fit persons below an effective altitude of 2640 metres. At higher altitudes, the adaptation is brought about by four main factors, viz., hyperventilation, increased diffusion of oxygen across alveolar membrane, erythrocythemia and maintenance of body hydration. Carbon dioxide sensitivity is markedly elevated at high altitude, both in sojourners and...

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ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 2015

ISSN: 0737-4038,1537-1719

DOI: 10.1093/molbev/msv100