INTESTINE AND LIVER HISTOPATHOLOGY OF STRIPED CATFISH (Pangasianodon hypophthalmus) FEEDING CONTAINING PAPAYA LEAF FERMENTATION

Aeromonas hydrophila bacteria often attack internal organs such as the liver and intestines. This research was conducted in June – August 2021 at Laboratory of Fish Parasites Diseases, Faculty Fisheries Marine, Universitas Riau. Histology preparations were made Bukittinggi Veterinary Center. aimed to obtain best dose addition papaya leaf fermented solution which could reduce intestinal tissue damage striped catfish (P.hypophthalmus) challenged with A.hydrophila. The method used is an experimental a completely randomized design (CRD) 4 treatment levels 3 replications; Kp (Feed not given + infected A.hydrophila), P1 (16 ml/kg feed P2 solution) P3 A. hydrophila). fish 8-10 cm density 1 fish/3 L totaling 10 container measuring 40x30x30 cm. Infection by injection intramuscular section much 0.1 mL/head bacterial 108 CFU/mL. parameters observed clinical symptoms for 72 hours histopathology intestine catfish. results showed that saw presence hemorrhage, necrosis, edema. While shows abnormalities, hypertrophy, fatty degeneration.