Intestinal Na+Loss and Volume Depletion in JAK3-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Intestinal ion transport in NKCC1-deficient mice.
The Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl(-) entry pathway. With targeted mutagenesis, mice deficient in the NKCC1 protein were generated. The basal short-circuit current did not differ between normal and NKCC1 -/- jejuna. In the -/- jejuna, the forskolin response (22 microA/cm(2); b...
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Expansion of early lymphoid progenitors requires interleukin-7 (IL-7), which functions through gamma(c)-mediated receptor activation of Jak3. Jak3 deficiency is a cause of severe combined immunodeficiency (SCID) in humans and mice. IL-3 activates many of the same signaling pathways as IL-7, such as Stat5, but achieves this effect through the activation of Jak2 rather than Jak3. We hypothesized ...
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ژورنال
عنوان ژورنال: Kidney and Blood Pressure Research
سال: 2013
ISSN: 1423-0143,1420-4096
DOI: 10.1159/000355731